The entire piece definitely has biblical connotations, demonstrated almost immediately by the closed triptych. The outer panels depict a transparent globe being formed from darkness, with the outlines of natural features materializing out of the gloom. Aside from setting the tone of the entire piece (a religious one), the closed panels reinforces the idea that the painting is a biblical narrative. The creation of the world is chronologically the first major event in Christian mythology, and Bosch made it clear that the theme of his work will be a biblical one.
Once opened, the panels show, from left to right, Adam and Eve with God in the Garden of Eden, humanity engaging in acts of hedonism, and the suffering of the damned in Hell.
Without describing every feature in detail, the general theme of the triptych seems to depict the fate of humanity right from Adam and Eve's original sin. They are shown here being joined in union by God as animals frolic in the Garden of Eden. This frolicking gives way to a chaotic scene of excess and lust, with animals in a state of frenzy and a large number of people engaging in what seems to be a mass orgy. The sinners are given their final punishment when they are damned to suffer in hell for the rest of eternity.
Perhaps Bosch intented his painting to be a depiction of what could befall humanity if they continued to engage in the hedonism he observed during his time.
